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Sodium change per litre of infusate: Adrogué-Madias

Acid-base & electrolytes

Predicts how much one litre of a given fluid will move the serum sodium. The planning tool for hyponatraemia and hypernatraemia correction.

What you enter

  • Serum sodium (mmol/L)
  • Infusate: 3% saline (513) / 0.9% saline (154) / Hartmann's / LR (130) / 0.45% saline (77) / 5% dextrose (0)
  • Weight (kg or lb)
  • Total body water fraction: Adult male (0.6) / Adult female (0.5) / Older male (0.5) / Older female (0.45)
FORMULAΔ Na = (infusate Na − serum Na) ÷ (TBW + 1)
SourceAdrogué HJ, Madias NE. Hyponatremia. NEJM 2000;342:1581-9ReviewedFormula and thresholds checked against the source on 2026-08-22. If the source updates, this line will say so.