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Carboplatin dose: Calvert formula

Oncology & dosing

Carboplatin is dosed to a target AUC, not to BSA, because renal clearance is what sets its exposure.

What you enter

  • Target AUC (mg/mL·min)
  • GFR (measured, or Cockcroft-Gault CrCl) (mL/min)
  • Cap GFR at 125 mL/min (FDA/most protocols): Yes / No
FORMULADose (mg) = target AUC × (GFR + 25)
SourceCalvert AH et al. Carboplatin dosage: prospective evaluation of a simple formula based on renal function. J Clin Oncol 1989;7:1748-56; GFR cap per FDA 2010 safety noticeReviewedFormula and thresholds checked against the source on 2026-08-22. If the source updates, this line will say so.